Our custom host cell line engineering service delivers a fully engineered and characterized host cell line, and allows you to modify any gene at any locus in your proprietary host cell line.  

• Enables flexible gene engineering approaches such as: gene ablation; gene defunctionalization; gene knock-in; inducible gene expression; point mutations; fusion tag
• Selected applications include: knockout of glutamine synthetase; knock-out of confounding glycosylation genes; and site-specific integration of landing-pads
• Zero off-target effects
• QC processes tailored to regulations surrounding therapeutic production 
• Human packaging cell lines derived from HEK 293 tested for the following human viruses: Adenovirus type 5; Hepatitis A; Herpes Simplex Virus 1; Human Immunodeficiency Virus 1; Rhinovirus; Reovirus type3; Vaccine virus
• Engineered host cell line tested for wild-type AAV (PCR & plaque assay)
• Proven technology in generating hundreds of genetically-defined cell lines