VIP-Cre Rat

TGRL9450

Animal Model
VIP-Cre

Nomenclature
LEH-VIP-Cretm1sage

Zygosity Genotype
Heterozygous

Colony Size
Available

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Technical Information
This model expresses cre-recombinase under the control of the endogenous vasoactive intestinal peptide (VIP) promoter enabling specific expression in VIP positive GABAergic interneurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the VIP gene. The VIP-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Health Report
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Research Applications

Research Application
• Optogenetics
• Expression/knockout of floxed genes
Research Area
Optogenetics Rats

Characteristics

Characteristics
• Cre recombinase driven by endogenous VIP promoter
• No observed ectopic expression of cre
• Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC
Background Strain: Long Evans Hooded
Figure 1
VIP-Cre Rat - Figure 1
Figure 1. VIP anti-sense probe mRNA in situ hybridization and anti-Tdtomato antibody staining confirms the correct expression pattern of Cre recombinase in the VIP positive neurons in the brain of VIP-cre, Rosa Tom rats.
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