Cell-line derived reference material for reliable and high precision validation of companion diagnostics. Gene coverage across the top oncology panels; formats include cfDNA, gDNA, FFPE and RNA. 

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Highly characterized human cell lines that use CRISPR-Cas9 gene-editing to disable genes of interest. Over 3000 pre-edited cell lines ready to ship.  

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The fastest custom generation service, with design to delivery capabilities.  Off the shelf KO models available including exclusive optogenetics. Expanding range of high fidelity PDX models.

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CRISPR
GENE EDITING

With over 4000 gene modifications completed across somatic, iPSC, germline and primary cells, we are gene editing experts and execute complex projects to agreed timelines.  As a premium service provider we validate to the highest quality standards. 

Our IP coverage allows us to choose from multiple technologies depending on project requirements. 

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GENE EDITING
AAV
rAAV

rAAV uses an exchange of nucleotide sequences to enable insertion, deletion or replacement of DNA sequences in cells. Unlike other methods this is achieved without causing a double strand DNA break.  

rAAV can be over 1,000 times more efficient at gene-targeting than plasmid-based methods and is an excellent tool for the generation of knockins, or any modifications that should involve a single allele.

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rAAV
ZFN
ZFN

ZFNs are engineered DNA binding proteins that can be designed to bind to a variety of DNA sequences by introducing a double stranded break at a specified location in the genome. This technique is particularly effective at knocking out gene function.

Technology license for use in custom in vivo gene-editing projects.

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ZFN
TRANSPOSON
TRANSPOSONS

Transposons are segments of chromosome that can be transposed to a new location within the DNA of a host cell. Transposon mutagenesis, or transposition mutagenesis, is a biological process that interrupts or changes cell DNA causing loss or gain of gene function or mutation.

This technique has been adapted for use in the laboratory as a method of gene editing.

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TRANSPOSONS

Spans product development and complex service solutions. Our execution ability is unparalleled.

Our Science

Lasting partnerships with Customers to deliver outstanding technical solutions. 

Collaborations

Make it happen. We have a one team approach ensuring the best outcomes for Customers. 

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Our Customers

Roche Novartis CytomX U ThermoFisher
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