Cell-line derived reference material for reliable and high precision validation of companion diagnostics. Gene coverage across the top oncology panels; formats include cfDNA, gDNA, FFPE and RNA.
Highly characterized human cell lines that use CRISPR-Cas9 gene-editing to disable genes of interest. Over 3000 pre-edited cell lines ready to ship.
The fastest custom generation service, with design to delivery capabilities. Off the shelf KO models available including exclusive optogenetics. Expanding range of high fidelity PDX models.
With over 4000 gene modifications completed across somatic, iPSC, germline and primary cells, we are gene editing experts and execute complex projects to agreed timelines. As a premium service provider we validate to the highest quality standards.
Our IP coverage allows us to choose from multiple technologies depending on project requirements.
rAAV uses an exchange of nucleotide sequences to enable insertion, deletion or replacement of DNA sequences in cells. Unlike other methods this is achieved without causing a double strand DNA break.
rAAV can be over 1,000 times more efficient at gene-targeting than plasmid-based methods and is an excellent tool for the generation of knockins, or any modifications that should involve a single allele.
ZFNs are engineered DNA binding proteins that can be designed to bind to a variety of DNA sequences by introducing a double stranded break at a specified location in the genome. This technique is particularly effective at knocking out gene function.
Technology license for use in custom in vivo gene-editing projects.
Transposons are segments of chromosome that can be transposed to a new location within the DNA of a host cell. Transposon mutagenesis, or transposition mutagenesis, is a biological process that interrupts or changes cell DNA causing loss or gain of gene function or mutation.
This technique has been adapted for use in the laboratory as a method of gene editing.