PXR Knockout Rat

TGRS4130

Animal Model
Nr1i2

Nomenclature
SD- Nr1i2 tm1sage

Zygosity Genotype
Homozygous

Colony Size
Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

Request a quote
OR
Technical Information
PXR is involved in the induction of cytochrome p4503A (Cyp3a) and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
PDF Download

Research Applications

Research Application
• Xenobiotic sensor
• Cytochrome p450 pathways
• Drug metabolism
• Hepatotoxicity
• Cholestasis
Research Area
Xenobiotic Sensors

Characteristics

Characteristics
• Biallelic 20 bp deletion within Nr1i2 gene
• Lacks induction of Cyp3a1
Background Strain: Sprague-Dawley
Figure 1
PXR Knockout Rat - Figure 1
Figure 1: Cyp mRNA induction in livers of PXR knockout and wild type Sprague-Dawley rats
Additional Information

Additional Information

Reviews

Write Your Own Review

You're reviewing: PXR Knockout Rat

How do you rate this product? *

 
1 1 star
2 2 star
3 3 star
4 4 star
5 5 star
Quality
Price
Value
Back to top