PXR/CAR/AHR Knockout Rat

TGRS9030

Animal Model
NR1i2/NR1i3/AHR

Nomenclature
SD-NR1i2/NR1i3/AHR tm1sage

Zygosity Genotype
Cryopreserved as heterozygous embryos

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
PXR, CAR, and AHR are involved in the induction of cytochrome p4503A (Cyp3a) and are abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)

Research Applications

Research Application
• Xenobiotic sensor
• Cytochrome p450 pathways
• Drug metabolism
• Hepatotoxicity
• Cholestasis
Research Area
Xenobiotic Sensors

Characteristics

Characteristics
• Biallelic 20 bp deletion within Nr1i2 gene
• Biallelic 10 bp deletion within Nr1i3 gene
• Biallelic 760 bp deletion within Ahr gene
Background Strain: Sprague-Dawley
Additional Information

Additional Information

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