Park2 Parkin Knockout Rat

TGRL4760

Animal Model
Park2

Nomenclature
LEH- Park2 tm1sage

Zygosity Genotype
Homozygous

Colony Size
Readily Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park2 (Parkinson disease [autosomal recessive, juvenile] 2) gene, encoding for the protein Parkin. Mutations in Parkin have been linked to early-onset Parkinson's disease (PD), making this model useful to further understand the role of Parkin in PD.
Download our review of Animal Models of Parkinson's Disease.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Parkinson's disease
• Dopaminergic cell toxicity
Research Area
Parkinson's Disease

Characteristics

Characteristics
• Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
• Park2 knockout rats show normal motor performance on rotarod
Background Strain: Long Evans Hooded
Figure 1
Park2 Parkin Knockout Rat - Figure 1
Figure 1: Loss of Parkin protein in Park2 knockout rats
Parkin protein expression is disrupted in Park2 knockout rats as compared to wild type controls as demonstrated by Western blot.
Figure 2
Park2 Parkin Knockout Rat - Figure 2
Figure 2. Rotarod performance of Park2 knockout rats at 12 months of agePark2 knockout animals show no deficits in motor activity as assessed by rotarod at 12 months of age.
Protocols & Documents
Additional Information

Additional Information

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