Mrp2 Knockout Rat

TGRS4340

Animal Model
Abcc2

Nomenclature
SD- Abcc2 tm1sage

Zygosity Genotype
Homozygous

Colony Size
Limited Availability

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Interested in a complete study? Horizon now offers our In Vivo Drug Transporter Assay service.Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• DMPKPK/PDFormulation
• Efflux assays
• Efficacy Drug-drug interactions
• Tissue distribution
• Dubin-Johnson syndrome
Research Area
Efflux Transporters

Characteristics

Characteristics
• Biallelic 726 bp deletion within Abcc2 gene
• Homozygous knockouts display total loss of protein via Western blot
• Decreased transport of endogenous glutathione
• Hyperbilirubinemia
Background Strain: Sprague-Dawley
Figure 1
Mrp2 Knockout Rat - Figure 1
Table 1. Glutathione level of Mrp2 (-/-) and wild type rats (nM/g)
Figure 2
Mrp2 Knockout Rat - Figure 2
Table 2. Serum chemistry for Mrp2 (-/-) and wild type rats
Additional Information

Additional Information

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