Interested in a complete study? Horizon now offers our In Vivo Drug Transporter Assay service. P-gp and Bcrp both play a critical role in efflux for brain. Double homozygous null Mdr1a-Bcrp rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp and Bcrp specific substrates.
• Biallelic 20 bp deletion within Abcba1 gene and 588 bp deletion within the Abcg2 gene • Increased oral bioavailability of P-gp and Bcrp specific substrates • Homozygous knockout rats display total loss of both proteins via Western blot • Background Strain: Sprague-Dawley