Mdr1a - Bcrp Knockout Rat

TGRS7490

Animal Model
Mdr1a/BCRP

Nomenclature
SD-Abcb1a- Abcg2tm1sage

Zygosity Genotype
Homozygous

Colony Size
Readily Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
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P-gp and Bcrp both play a critical role in efflux for brain. Double homozygous null Mdr1a-Bcrp rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp and Bcrp specific substrates.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• DMPK Assay
• PK/PDEfflux Assay
• Neurotoxicology
• Formulation
• Drug-drug interactions
• Drug resistance
• Blood brain barrier efflux
• Efficacy
Research Area
Efflux Transporters

Characteristics

Characteristics
• Biallelic 20 bp deletion within Abcba1 gene and 588 bp deletion within the Abcg2 gene
• Increased oral bioavailability of P-gp and Bcrp specific substrates
• Homozygous knockout rats display total loss of both proteins via Western blot
Background Strain: Sprague-Dawley
Protocols & Documents
Additional Information

Additional Information

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