Mdr1a/1b Knockout Rat

TGRS7070

Animal Model
Abcb1a-Abc1b

Nomenclature
SD- Abcb1a-Abc1btm1sage

Zygosity Genotype
Homozygous

Colony Size
Readily Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Interested in a complete study? Horizon now offers our In Vivo Drug Transporter Assay service.
P-glycoprotein plays a critical role in efflux for both brain and liver. Homozygous null Mdr1a rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp-specific substrates.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• DMPK Assay
• PK/PDEfflux Assay
• Neurotoxicology
• Formulation Drug-drug interactions
• Drug resistance
• Blood brain barrier efflux
• Efficacy
Research Area
Efflux Transporters

Characteristics

Characteristics
Background Strain: Sprague-Dawley
Additional Information

Additional Information

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