Ldlr Knockout Rat

TGRS4060

Animal Model
Ldlr

Nomenclature
SD- Ldlr tm1sage

Zygosity Genotype
Heterozygous

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Atherogenesis
• Atherosclerosis
• Hypertension
• Insulin resistance
• Lipoprotein/Cholesterol transportation
• Metabolism (Triglyceride/Cholesterol)
• ObesityType II diabetes
Research Area
Cardiovascular

Characteristics

Characteristics
• This model possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8
• Homozygous knockout rats display loss of LDLR protein via Western blot
• Homozygous knockout rats have increased body weight as compared to wild type
• Homozygous knockout rats show significantly elevated serum cholesterol levels
Background Strain: Sprague-Dawley
Figure 1
Ldlr Knockout Rat - Figure 1
Figure 1: Homozygous Ldlr knockout rats demonstrate significantly higher cholesterol levels at 5-weeks of age
5-week-old Ldlr knockout rats display increased serum cholesterol levels both pre- (A) and post-fasting (B) as compared to wild type animals.
Additional Information

Additional Information

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