For over 150 years, the common laboratory rat has been used as a model for human disease research as its size, cognitive abilities and physiology make it ideal for the study of a wide range of human disease.
What is a knockout mouse or knockout rat?
A knockout (or knock down) laboratory rodent is an animal model that has been engineered with a specific gene (or genes) disabled. They aid study of gene function and drug development in academic or pharmaceutical research into human diseases & genetic conditions.
Formerly Sage Labs, Horizon partners with the leading minds in ADMET, neurobiology, cardiovascular biology, and oncology to develop our SAGE® rodent research models for advanced disease research.
We have one of the widest ranges of genetically engineered and custom knockout rat models using CRISPR technology complimented with a range of services for drug discovery & basic research. This includes Neuroscience, ADMET, Cardiovascular and Oncology with more models being constantly developed.
|Parkinson's Disease||Alzheimer's Disease||Autism||Schizophrenia||Pain||Optogenetics|
|Park2||Humanized ApoE4||Pten||Chrna7||Oprm1||tdTomato Reporter|
|Rbfox1||Cre lines coming soon:|