In Vivo Research Models

In vivo research models engineered to help researchers understand complex genetic diseases

Horizon has a continually expanding portfolio of proprietary, off-the-shelf knockout rat models designed for advanced disease research

We partner with the leading minds in ADMET, neuroscience, cardiovascular biology, immunology and oncology to develop our SAGE® rat research models.

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Our in-vivo development specialists can help you design a custom, genetically engineered animal model that meets your exact requirements.

Utilizing our licensed CRISPR (Caribou Biosciences / Broad Institute) or ZFN technologies, a custom animal model can be delivered to your lab in as little as 5 months.

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If you want to generate your own in vivo models, Horizon can support you with the highest quality reagents.

We provide access to professional in vivo-grade, microinjection ready CRISPR reagents expertly designed by the leading experts in genetic engineering.

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Developing a new tumor model is time-consuming, requires significant investment and skilled resources to characterize.

Save time and money with our comprehensive service, simply provide your dissociated cells or tissue, our state of the art facility provides characterization of the tumor growth.

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SAGE® transgenic services range from custom model generation to colony expansion, maintenance, and cryopreservation services backed by top researchers and best practices in animal husbandry.

Use of CRISPR/Cas9 to customize mouse models has enabled Horizon to speed up creation of transgenic rodents by eliminating the need for embryonic stem cells to generate genetic modifications.

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Patient Derived Xenograft (PDX) models are typically implanted as dissociated cells or tumor fragments into immunodeficient mouse models to be used for in-vivo efficacy studies.

We have partnered with exceptional institutions to provide highly characterized patient derived xenograft models of breast cancers and melanomas for your research.

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