Isogenic Cell Lines

Horizon's cell lines are genetically engineered cell pairs containing defined genomic modifications, providing a model system for the study of the role of genes in cellular processes and drug responses. Cell lines are provided with a matched wild type control parental cell line ensuring phenotypes can be attributed directly to the genotype.

Using Horizon’s paired cell lines you can:

  • Study loss or gain of function mutations at the endogenous level
  • Initiate target identification and validation studies
  • Identify responsive or resistant patient populations in a human cell line model
  • Analyse expression, protein interactions and localization using endogenously tagged genes

These models complement and surpass non-isogenic cell lines where findings are difficult to understand due to the absence of a normal control cell.

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