What Is SUMOylation?
Definition: SUMOylation is a reversible post-translational modification involved in transcription, DNA repair, chromatin remodeling, splicing, assembly of ribosomes and many other cellular processes.
SUMOylation is a reversible post-translational modification involved in transcription, DNA repair, chromatin remodeling, splicing, assembly of ribosomes and many other cellular processes. SUMO (small ubiquitin-like modifier) is attached as a monomer or polymer through a process akin to that of ubiquitination. It is attached via the sequential action of E1, E2 and E3 enzymes, and can be removed by SUMO1/Sentrin-specific proteases SENPs).
To support your research on the role and mechanism of SUMO modifications, Horizon has developed a collection of human knockout HAP1 cell lines that lack components of the SUMOylation pathway. These knockouts enable study of pathway redundancy, identification of subcellular function and characterization of the proteins themselves by providing a clean background in which mutants can be expressed.
|Examples of popular knockout cell lines|
Our cell line range is constantly growing. For our most current list of ready-made cell lines and details of custom made engineering projects you can browse our entire offering via the link below.
For offline access, many of our popular cell lines that are usually available for immediate delivery are listed in our downloadable our catalog - your gene edited cell line may already have been created!