This model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. APP can be cleaved by the beta and gamma secretases, forming beta amyloid. Beta amyloid can self-aggregate to form amyloid plaques, one of the hallmarks of Alzheimer's disease.
- Diet Value
LabDiet #5R24 (RMH2500)
- Age Weight Curve
- Research Application
• Alzheimer's disease
• Memory loss
• Synaptic formation and repair
- Research Area
• Homozygous knockout rats exhibit complete loss of protein
• Background Strain: Sprague-Dawley
- Figure 1
Figure 1: Homozygous APP knockout rats exhibit complete loss of APP
Western blot analysis of brain tissue shows a complete absence of APP in homozygous knockout rats (-/- = homozygous knockout,+/+ = wild type).