App Knockout Rat

TGRS5460

Animal Model
App

Nomenclature
SD- App tm1sage

Zygosity Genotype
Cryopreserved as heterozygous embryos

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. APP can be cleaved by the beta and gamma secretases, forming beta amyloid. Beta amyloid can self-aggregate to form amyloid plaques, one of the hallmarks of Alzheimer's disease.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve

Research Applications

Research Application
• Alzheimer's disease
• Neurodegeneration
• Memory loss
• Dementia
• Synaptic formation and repair
Research Area
Alzheimer's Disease

Characteristics

Characteristics
• Homozygous knockout rats exhibit complete loss of protein
Background Strain: Sprague-Dawley
Figure 1
App Knockout Rat - Figure 1
Figure 1: Homozygous APP knockout rats exhibit complete loss of APP
Western blot analysis of brain tissue shows a complete absence of APP in homozygous knockout rats (-/- = homozygous knockout,+/+ = wild type).
Additional Information

Additional Information

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