AHR Knockout Rat

TGRS8890

Animal Model
Ahr

Nomenclature
SD- Ahr tm1sage

Zygosity Genotype
Homozygous

Colony Size
Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
AHR is involved in the induction of cytochrome p450s and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Xenobiotic sensor
• Cytochrome p450 pathways
• Drug metabolism
• Hepatotoxicity
• Cholestasis
Research Area
Xenobiotic Sensors

Characteristics

Characteristics
• Biallelic deletion of Ahr
Background Strain: Sprague-Dawley
Figure 1
AHR Knockout Rat - Figure 1
Figure 1: Loss of Cyp1a1, Cyp1a2 and Mrp3 (Abcc3) induction in Ahr (-/-) rats after TCDD treatment.
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