5Ht3a-Cre Rat

TGRL9380

Animal Model
5Ht3a-Cre

Nomenclature
LEH- 5Ht3a-Cretm1sage

Zygosity Genotype
Homozygous

Colony Size
Limited Availability

$0.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model expresses cre-recombinase under the control of the endogenous 5’- hydroxytryptamine receptor 3A (5Ht3a) promoter enabling specific expression in 5Ht3a positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the 5Ht3a gene. The 5Ht3a-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Health Report
PDF Download

Research Applications

Research Application
• Optogenetics
• Expression/knockout of floxed genes
Research Area
Optogenetics Rats

Characteristics

Characteristics
• Cre recombinase driven by endogenous 5Ht3a promoter
• No observed ectopic expression of cre
• Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC
Background Strain: Long Evans Hooded
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