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shRNA & Overexpression Reagents

In addition to endogenous gene-editing, overexpression and knockdown studies are indispensable approaches for basic and clinical research to determine the role of a gene and hence to find novel targets for putative new drugs.

Since the discovery of RNAi technology in the last century, the research field has been revolutionized. Rational algorithm-based design of shRNA sequences has been successfully used for the identification of active shRNA sequences. However knockdown efficiency of these sequences is generally 70% or less, and so only leads to partial gene knockdown, calling into question the validity of results.

To address this issue, Horizon has entered into a partnership with SIRION BIOTECH, whose core competence lies in the development of high efficiency shRNAs through the proprietary RNAiONE™ platform and translating this system onto a comprehensive viral vector platform. RNAiONE identifies shRNA sequences with a high gene silencing efficiency, often over 90%, allowing researchers to have more confidence that their knockdown experiments will have real meaning.

Click here download our shRNA & Overexpression Reagents Brochure Insert

Order Sirion Products and Services online:

Search and Order off-the-shelf shRNA and cDNA expression reagents and custom services.

Order Sirion Reagents

Order Sirion Custom Services

Alternatively for more information contact us at info@horizondiscovery.com

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