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Off The Shelf Plasmid Library

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Cas9 is the protein component of CRISPR microbial nuclease system gene editing, and is responsible for generating cuts in DNA. Horizon offers two versions; wild-type which generates cuts on both strands for a double-stranded break; and nickase, which has a D10A mutation so that it only cuts a single strand. By using the nickase form of Cas9 with two guide RNAs targeting opposite strands of the target DNA, a double-strand break is achieved with reduced off-target activity.

A variety of plasmid vectors expressing Cas9, guides (single or for double nickase approach) or combined Cas9 and guides are available from Horizon.

Get advice from our gene editing experts!

1 hour free expert scientific support with every off the shelf order of $400 or more

Order GENASSIST™ Products and Services online:

Horizon Discovery is interested in licensing many of the cell lines that are being developed by our customers in return for a royalty. There is no commitment from you to do so and please inform Horizon if you are interested in participating.

Order Off The Shelf Plasmids

Alternatively for more information contact us at info@horizondiscovery.com

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