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Custom Screening Services

Horizon provides definitive and controlled preclinical model systems through the use of isogenic cell lines, where the genetic modification of interest can be directly compared to its matched normal cell. The use of panels of these isogenic cell lines allows molecularly-defined cellular models to be systematically profiled, thereby providing a powerful tool for the investigation of sensitivity and resistance to cancer therapeutics.

Horizon has further coupled our isogenic cell line library with our understanding of cancer biology and the tumor microenvironment, along with siRNA libraries and automation systems to be able to offer a range of screening approaches and assay conditions suitable to meet the requirements of almost any project.

Click here download our Custom Screening Services Brochure Insert

Cell Line screening panels

Horizon’s screening panels have been designed to enable customers wishing to use Horizon’s isogenic cell lines to probe the effect of their compounds against patient-relevant cancer mutations. 

Cell line screening panels are available in two formats:

  • Generic panels have been designed to probe against major cancer causing genotypes, and
  • Custom selections of cell lines chosen to answer customers’ specific questions.  

Horizon also has the ability to perform high throughput combination screening.

Learn more about CombinatoRx™ combination screening services  

Large scale siRNA or compound screening

To support customers with large-scale screening projects, Horizon has invested in automated liquid handling capabilities and barcoded sample tracking and annotation.  This in combination with our isogenic cell line catalog, enables us to offer both compound and siRNA screening panels tailored specifically to customers’ requirements.

Hamilton robotic automation system for large-scale screening projects

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