CombinatoRx is complementary to Horizon's current drug discovery and development capabilities
Horizon CombinatoRx has created a fully integrated and highly automated high throughput platform, allowing us to screen thousands of drug and other molecule combinations across large panels of well annotated cell lines. This approach allows us to reveal potency shifts or efficacy boosts, identify multi-target mechanisms important for combination activity, cell lines with specific genomic signatures that selectively respond to combination drug treatment for patient stratification and to identify compounds that antagonize the activity of drugs you are developing.
We have spent more than a decade designing and refining our platform and proprietary analytic software capabilities. We believe that combination drug discovery and analysis should be a core competency for any drug company, particularly those developing cancer drugs. Let us help you to position your assets for success in the clinic.
CombinatoRx has a long and distinguished track record working on combination drug discovery with both pharmaceutical and biotech companies. Projects have included the combination screening of small molecules, biologics (antibodies, peptides) and hybrid molecules (such as antibody-drug conjugates).
These companies choose to work with us because of:
- Our deep expertise in combination sciences and the unmatched quality of work
- The efficiency of screening has been optimized with respect to workflow and costs, making CRx screening a cost effective option versus performing the work in-house
- Our ability to deliver data from large screening efforts in a timely manner and bring value to a development program
CRx works closely with partners to ensure the success of their project and, with over a decade of combination sciences experience, you are able to utilize our expertise for project design and interpretation of results. We can help you identify selective enhancers or novel synergistic combinations of pipeline candidates, approved agents, or key mechanisms.