The following webcasts are scheduled. Participation is free, so please register to participate.
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Date: December 9th, 2014 16: 00-16: 30 GMT (London time)
Horizon is a world-leader in genome-editing, and in this free webinar we discuss our approach to RNAi screening using siRNA and CRISPR-Cas9 sgRNA technologies. Topics will include introduction to RNAi technologies, use of X-MAN™ isogenic cell lines in RNAi screening approaches, comparison of siRNA and sgRNA screening approaches, possibilities and challenges of genome-wide CRISPR-Cas9 knockout (GeCKO) screening, and examples of synthetic lethal screenings using siRNA and CRISPR-Cas9 sgRNA technologies for target identification and patient stratification.
Date: December 11th, 2014 16: 00-16: 40 GMT (London time)
The use of formalin fixative stems from its ability to cross-link proteins, however it has also been reported to induce methylol modifications and acid-mediated hydrolysis which can confound genotyping analysis. Similarly, variability in the fixation time, delay of fixation and type of fixation effect tumor biopsies and subsequent sequencing. Here, we present the design and validation of our Formalin-Compromised HDx Reference Standards with precisely defined molecular weights that mimic formalin-treated samples and their performance in assays. We will discuss the effects of formalin on clinical diagnostics and how these can be minimized.
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