Isogenic Disease Models
Isogenic cell-lines, recapitulate the genetic mutations found in diseases such as cancer and provide a perfectly matched reference normal genetic background to determine the effects of that gene on the cells’ function and its responses to appropriately targeted agents.
By screening potential drug-candidates on such well defined diseased vs. normal cell-lines, clear information on a drug’s mechanism, therapeutic window and responsiveness can now be obtained prior to entering expensive clinical trials.
Key to the efficient generation of human isogenic cell-lines and the range of genes that can be stably-altered at endogenous levels is the proprietary GENESIS virally-mdeiated isogenic gene targeting platform. [