Products
Horizon Discovery’s offering is based upon the supply of a range of human cell-lines that represent patient-relevant isogenic somatic models of human genetic diseases.
X-MAN (mutant & normal) cell-lines are available that model many of common genotypes observed in human cancer, plus provide their perfectly matched normal genetic backgrounds as a reference.
X-MAN cell lines separate the cancer-gene spectrum to aid the discovery of specifically targeted drugs that can be used singularly, or in combination.
Targeting single defects using the X-MAN Discovery 1 panel of cell lines is the first step into understanding how different patient populations respond to a drug; but it is becoming critical to check if other (secondary) mutations impart resistance. This is a key feature of the X-MAN Discovery 2 panel of cell lines (or double Knock-ins).
X-MAN Researcher lines are targeted to secondary, epigenetically regulated or modifier genes that are differentially expressed in cancer vs. normal cells.
Finally, the X-MAN Express range of protein cell-lysates enablethe study of fundamental proteomics research applications.
Academic, Biotech and Pharma customers are already discovering the power of X-MAN cell-lines in a range of drug discovery, drug development and general research applications.
Horizon X-MAN Isogenics Offering
Q3 2009 X-MAN Inventory
