Advances in DNA sequencing have allowed the genomes of nearly 200 species to be determined, unlocking the possibility to:

• Define and understand genetic diversity and the molecular basis of disease in humans, animals and plants
• Manipulate the genomes to deliver enhanced yields of crops and biopharmaceuticals
• Identify novel personalized medicines targeted to the patient populations with a genetic profile that predicts a positive clinical outcome

The challenge of unlocking this wealth of information, known as 'translational genomics' is the ability to engineer functional test systems (cell lines) that precisely recapitulate the genetic features under experimental investigation.

Horizon can deploy, on your behalf, the most precise and flexible genome-editing solution available so that any DNA sequence can be inserted, deleted or substituted at any target endogenous locus in any parental cell line. Spatial, inducible and conditional targeting strategies can be deployed meaning your biological question (rather than the limits of the technology platfrom) can always be put first.

More information on rAAV GENESIS™, our translational genomics platform.

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