X-MAN™ cell lines are patient relevant disease models and have become essential translational genomic tools that comprise some or all of the following key features:

• Genetically-defined alterations made in endogenous genes of human cells that accurately recapitulate the disease causing mutations as they occur in real patients
• Targeted integration of endogenous pathway reporters that read-out downstream effects of any targeted therapy or introduced genomic alteration
• Cell line pairs that are isogenic i.e., they share the same genetic background, allowing the ultimate definitive study of specific genetic variances with reference to the normal cells and removing any complications introduced by comparing different patient cells which vary via a multitude of genetic features

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It can take as long as 16 weeks or more with costs often running into the tens of thousands of dollars in reagents and personnel time to generate a custom cell line, which is then followed by a detailed validation process to demonstrate that a generated cell line harbors a single-copy of the genomic feature of interest (without any confounding off-target effects prevalent with nucelase-based targeting approaches). Horizon’s extensive and growing menu of over 500 X-MAN™ cell lines and endogenous pathway and imaging reporter kits provide you with access to pre-made and highly validated cell lines and tools for a fraction of the cost of in-house development.

Learn more about our menu of X-MAN™ cell lines and X-MAN™ Reporter Kits