Horizon's expertise in understanding the key genetic drivers of cancer has been applied in conjunction with GENESIS™ to develop the award winning X-MAN® (Gene-X, Mutant And Normal) human isogenic disease models. These have become colloquially known as 'patients-in-a-test-tube'.
X-MAN® cell lines are patient relevant disease models and have become essential translational genomic tools that comprise some or all of the following key features:
It can take as long as 16 weeks or more with costs often running into the tens of thousands of dollars in reagents and personnel time to generate a custom cell line, which is then followed by a detailed validation process to demonstrate that a generated cell line harbors a single-copy of the genomic feature of interest (without any confounding off-target effects prevalent with nuclease-based targeting approaches). However, Horizon’s extensive and growing menu of almost 600 X-MAN® cell lines and endogenous pathway and imaging reporter kits provide you with access to pre-made and highly validated cell lines and tools for a fraction of the cost of in-house development.