Discover Our Science

To date, Horizon has used the GENESIS™ genome-editing platform to create an extensive collection of X-MAN® (gene-X Mutant And Normal) isogenic cell lines, the world’s first source of genetically-defined and patient-relevant human cellular models, with more being developed continually. These disease models comprise two cell lines that are identical except for the targeted modification, allowing for the accurate study of normal vs. diseased biology, the identification or validation of novel drug targets, or the identification, development and prescription of targeted or ‘personalized’ medicines.

Horizon provides a range of GENESIS™ and X-MAN® derived products and services, with clear industrial applications in: bio-pharmaceutical process optimization; clinical diagnostic development; drug discovery & development; and the provision of reference standards for genomics-based clinical research platforms.

Horizon's science base and technology platforms are substantiated by over 400 peer reviewed publications, involvement in 5 multi-national grant-funded translational research consortia, partnering in over 50 academic research collaborations and the establishment of over 30 human gene-editing Centers of Excellence.

Login Error

There was an error with your login - please try again.

Forgotten your password? Click here

OK ×

Recover your password

Please enter your email address and we'll send you a reset link


Thank you.

We've sent you an email to reset your password.

OK ×

Add Voucher

Sorry, Unable to add voucher

OK ×

Account Error

There was an error updating your details.

OK ×

Thank you.

Your changes have been saved.

OK ×

Thank you

Thank you for registering to the Horizon Discovery website. We hope you enjoy and benefit from our online resources, and please feel free to contact us if you have any queries or feedback through the website itself or at

Got a few seconds to tell us what you're interested in?

Tick all that apply:

Horizon’s Offerings

Application Area

Disease Area


Other Disease Area (Please specify)


Thank you.

Items have been saved to your basket.

OK ×