Key Milestones and Achievements
Key Milestones & Achievements
- Grown from 0 to >110 FTEs housed in state of art 40,000 sq. ft. laboratory and office facilities in Cambridge, UK and Cambridge, MA, USA
- Revenue CAGR of greater than 125% for period 2008 to 2013
- Listed on the AIM market of the London Stock Exchange raising £68.6M an all-time record for a Life Science Company
- Acquired CombinatoRx service business and asserts from Zalicus Inc for £4.74M
- Winner of Biomedtech Company of Year for East of England Region 2013
- Winner of European Mediscience’s Emerging Star Award 2014
- Winner Santander Breakthrough 50 Award, 2014
- Winner of the 'Licensing Deal of the Year' with AstraZeneca, Scrip Awards 2013
- Winner of most promising company at world conference on Personalized Medicine 2013
- Winner of the Queen's Award for Enterprise 2012, for International Trade
- Launched panel of 550 X-MAN® cell line products; 15 new assay kits; 50 2D and 3D cell-based phenotypic assays and 1000 genomic reference standard products
- Entered into two drug discovery collaborations with AstraZeneca, with upfront and preclinical milestone payments, and eligible for clinical and approval milestones totaling more than £100M, as well as tiered royalties
- Established distributors in Singapore, South Korea, Japan, Italy, and other regions
- Entered into exclusive partnership with Crown Bioscience Inc. to offer in vivo services utilizing Horizon's X-MAN™ cell lines
- Launched a suite of endogenous reporter gene assay kits with our commercial partner Promega Corporation
- Established an oncology research service collaboration with Boehringer Ingelheim
- Award of £3.5M grant funding from The Seventh Framework Program for COLTHERES, PREDICT, INSIGHT, SeaBiotech & 4D CellFate Consortia
- Establishment of over 40 rAAV human gene-editing Centers of Excellence including the US National Institutes of Health (NCI & NHGRI)
- Alliances with 100 academic collaborators including ICR (Ashworth Lab)
- Launched SyntheTx™ target identification platform with H3 Biomedicine Inc
- Seminal publications by Professor Alberto Bardelli (Horizon co-founder) in the Journal of Cancer Research (March 2007), the Journal of Clinical Oncology (October 2008) and Journal of The American Medical Association (October 2010) detailing a retrospective analysis of colon cancer patients that has led the EMEA and FDA to mandate testing for the presence or absence of ‘mutant’ KRAS before the anti-EGFR targeted agents Vectibix® and the blockbuster Erbitux® are prescribed as front-line treatment to colorectal cancer patients
- Seminal Nature paper in 2012 from Professor Alberto Bardelli (Horizon co-founder) showing the real-time EGFR resistance feedback loop for the B-Raf (V600E) targeted melanoma drug Vemurafanib in B-Raf (V600E) positive colorectal cancer patients and the overcoming of this resistance using combinations of Vemurafanib and EGFR target drugs Erbitux® and Erlotinib
- Achieved ISO 9001 and ISO 13485 standards
- Licensed ZFN and CRISPR gene-editing technologies, making Horizon the only company to have access to both rAAV and nucleases
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