Key Milestones and Achievements
Key Milestones & Achievements
- Grown from 0 to 80 FTEs housed in state of art 17,800 sq. ft. facility in Cambridge, UK
- CAGR of greater than 100% over the first five years of operation
- Winner of the 'Licensing Deal of the Year' with AstraZeneca, Scrip Awards 2013
- Winner of the Queen's Award for Enterprise 2012, for International Trade
- Launched panel of 500 X-MAN™ cell line products; 15 new assay kits; 50 2D and 3D cell-based phenotypic assays and 100 genomic reference standard products
- Entered into a drug discovery collaboration with AstraZeneca, with upfront and preclinical milestone payments, and eligible for clinical and approval milestones totaling more than £70M, as well as tiered royalties
- Established distributors in Singapore, South Korea, Japan, Italy, and other regions
- Entered into exclusive partnership with Crown Bioscience Inc. to offer in vivo services utilizing Horizon's X-MAN™ cell lines
- Launched a suite of endogenous reporter gene assay kits with our commercial partner Promega Corporation
- Established an oncology research service collaboration with Boehringer Ingelheim
- Award of £3.5M grant funding from The Seventh Framework Program for COLTHERES, PREDICT, INSIGHT, SeaBiotech & 4D CellFate Consortia
- Establishment of 30 rAAV human gene-editing Centers of Excellence including the US National Institutes of Health (NCI & NHGRI)
- Previous funding rounds have led to circa £20M of financing from premier investor groups including DFJ Esprit LLP, Genentech Inc., and Roche Venture Fund
- Alliances with 100 academic collaborators including ICR (Ashworth Lab)
- Launched SyntheTx™ target identification platform with H3 Biomedicine Inc
- Seminal publications by Professor Alberto Bardelli (Horizon co-founder) in the Journal of Cancer Research (March 2007), the Journal of Clinical Oncology (October 2008) and Journal of The American Medical Association (October 2010) detailing a retrospective analysis of colon cancer patients that has led the EMEA and FDA to mandate testing for the presence or absence of ‘mutant’ KRAS before the anti-EGFR targeted agents Vectibix® and the blockbuster Erbitux® are prescribed as front-line treatment to colorectal cancer patients
- Seminal Nature paper in 2012 from Professor Alberto Bardelli (Horizon co-founder) showing the real-time EGFR resistance feedback loop for the B-Raf (V600E) targeted melanoma drug Vemurafanib in B-Raf (V600E) positive colorectal cancer patients and the overcoming of this resistance using combinations of Vemurafanib and EGFR target drugs Erbitux® and Erlotinib
- Winner of most promising company at world conference on Personalized Medicine 2013
- Achieved ISO 9001 and ISO 13485 standards
- Licensed ZFN and CRISPR gene-editing technologies, making Horizon the only company to have access to both rAAV and nucleases
Paragraph explaining benefits of Biocair
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