Rag1 Knockout Rat | Sprague-Dawley

TGRS3920

Animal Model
Rag1

Nomenclature
SD- Rag1 tm1sage

Zygosity Genotype
Cryopreserved as heterozygous embryos

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve

Research Applications

Research Application
• Xenograft
• Cancer metastasis
• Vaccine development
• Inflammation/Autoimmune disorders
• Thrombosis/Cardiac fibrosis
• Vascular defects
• Hematopoieses
• Infectious disease
Research Area
Immunology/Inflamation and Immunodeficient

Characteristics

Characteristics
• 29 bp deletion within Exon 2 on chromosome 3
• Homozygous Rag1 knockout rats display loss of RAG1 protein via Western blot
• Homozygous Rag1 knockout rats show loss of B and T cells by FACS analysis
Background Strain: Sprague-Dawley
Figure 1
Rag1 Knockout Rat | Sprague-Dawley - Figure 1
Figure 1: Flow cytometric analysis of T cell subsets (CD4 and CD8), B cells and NK cells from wild type and Rag1 (-/-) knockout blood samples
The top panels represent wild type female and male rats. The lower panels represent samples from female and male Rag1 (-/-) knockout rats. Blood samples were collected from 4-, 10- and 20-week-old rats.
Protocols & Documents
Additional Information

Additional Information

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