Pink1 Knockout Rat - Park6

TGRL4690

Animal Model
Pink1, Park6

Nomenclature
LEH- Pink1 tm1sage

Zygosity Genotype
Homozygous

Colony Size
Readily Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson's disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson's disease.
Download our review of Animal Models of Parkinson's Disease.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Parkinson's disease
• Stress-induced neurological dysfunction
Research Area
Parkinson's Disease

Characteristics

Characteristics
• Homozygous knockout rats exhibit complete loss of target protein
• Approximately 30% of Pink1 knockout rats display a hindlimb-dragging phenotype at 5 months of age
• Pink1 knockout rats show increased hindlimb fatigue at 7 weeks of age
• Pink1 knockout rats show increased number of hindlimb foot slips at 5 and 9 weeks of age as assessed by tapered balance beam
• Preliminary reports have suggested Pink1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age
Background Strain: Long Evans Hooded
Figure 1
Pink1 Knockout Rat - Park6 - Figure 1
Figure 1: Increased fatigue in Pink1 knockout rats
Pink1 homozygous and heterozygous knockout rats display decreased movement in an open field after hindlimb fatigue challenge, indicative of increased hindlimb fatigue.
Figure 2
Pink1 Knockout Rat - Park6 - Figure 2
Figure 2. Decreased performance on tapered balance beam in Pink1 knockout rats
Pink1 homozygous and heterozygous knockout rats display increased hindlimb foot slips on a tapered balance beam. No differences were seen in forelimb foot slips.
Protocols & Documents
Additional Information

Additional Information

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