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Horizon is pleased to exclusively offer the largest collection of well-characterized patient-derived xenograft (PDX) models of melanoma available today. Horizon has partnered with The Wistar Institute of Anatomy and Biology in Philadelphia, Pennsylvania to make available their large collection of highly characterized Melanoma PDX models to the research community. These melanoma models are representative of all previously well-described melanoma subtypes identified by the Cancer Genome Atlas (TCGA).
The Wistar Institute’s melanoma PDX collection has been developed by Clemens Krepler and Meenhard Herlyn. This collection has undergone a great deal of characterization, and continues to be subjected to characterization with the evolution of therapies being assessed in the research community (for example, twelve of the models in this collection have been published in Krepler, et al., Clinical Cancer Research, 2016.
Figure 1. Growth Curve for a Wistar Melanoma PDX model. Three NSG™ mice were implanted with minced fragments of WM4007, from mouse passage 1, subcutaneously. The growth of each individual PDX was monitored and measured using calipers.
Horizon will offer a number of services around the Wistar melanoma PDX collection, including in vivo efficacy studies and ex vivo proliferation studies.