Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park7 (Protein deglycase DJ-1) gene, encoding for the protein DJ-1. Mutations in DJ-1 have been linked to autosomal recessive early-onset Parkinson's disease (PD), making this model useful to further understand the role of DJ-1 in PD. Download our review of Animal Models of Parkinson's Disease.
• Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot • Approximately 30% of DJ-1 knockout rats show a hindlimb-dragging phenotype that emerges at 4-6 weeks of age and worsens at 5 months • DJ-1 knockout rats show impaired open-field mobility at 8 months of ageDJ-1 knockout rats show gait impairments at 8 months of age • Preliminary reports have suggested DJ-1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age • Background Strain: Long Evans Hooded
Figure 1: Decreased open-field mobility in DJ-1 knockout rats Impairments in open-field mobility were seen in 5 of 15 DJ-1 knockout rats at 8 months of age.
Figure 2. Impaired gait in DJ-1 knockout rats DJ-1 knockout rats show impaired gait in an open field. Impairment was seen in 5 of 15 animals at 8 months of age.