Park7 DJ-1 Knockout Rat

TGRL4830

Animal Model
Park7

Nomenclature
LEH- Park7 tm1sage

Zygosity Genotype
Homozygous

Colony Size
Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park7 (Protein deglycase DJ-1) gene, encoding for the protein DJ-1. Mutations in DJ-1 have been linked to autosomal recessive early-onset Parkinson's disease (PD), making this model useful to further understand the role of DJ-1 in PD.
Download our review of Animal Models of Parkinson's Disease.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Parkinson's disease
• Dopaminergic cell toxicity
Research Area
Parkinson's Disease

Characteristics

Characteristics
• Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
• Approximately 30% of DJ-1 knockout rats show a hindlimb-dragging phenotype that emerges at 4-6 weeks of age and worsens at 5 months
• DJ-1 knockout rats show impaired open-field mobility at 8 months of ageDJ-1 knockout rats show gait impairments at 8 months of age
• Preliminary reports have suggested DJ-1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age
Background Strain: Long Evans Hooded
Figure 1
Park7 DJ-1 Knockout Rat - Figure 1
Figure 1: Decreased open-field mobility in DJ-1 knockout rats
Impairments in open-field mobility were seen in 5 of 15 DJ-1 knockout rats at 8 months of age.
Figure 2
Park7 DJ-1 Knockout Rat - Figure 2
Figure 2. Impaired gait in DJ-1 knockout rats
DJ-1 knockout rats show impaired gait in an open field. Impairment was seen in 5 of 15 animals at 8 months of age.
Protocols & Documents
Additional Information

Additional Information

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