This model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Along with TrkA, p75NTR is a receptor for the nerve growth receptor and is important in nociception. The p75NTR knockout rat is useful for pain research.
- Diet Value
LabDiet #5R24 (RMH2500)
- Age Weight Curve
- Health Report
- Research Application
• Neuronal development
- Research Area
• Homozygous knockout rats exhibit complete loss of p75NTR protein
• p75NTR knockout rats show hyposensitivity to thermal pain via hot plate assay
• p75NTR knockout rats show increased reactivity to touch in a functional observational battery (Irwin)
• Background Strain: Sprague-Dawley
- Figure 1
Figure 1: Thermal insensitivity in p75NTR knockout rats.
p75NTR knockout rats show increased foot licking latency in the hot plate test.
*** = p < 0.001.