p75NTR Knockout Rat

TGRS5670

Animal Model
Ngfr

Nomenclature
SD- Ngfr tm1sage

Zygosity Genotype
Cryopreserved as Heterozygous embryos

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Along with TrkA, p75NTR is a receptor for the nerve growth receptor and is important in nociception. The p75NTR knockout rat is useful for pain research.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
PDF Download

Research Applications

Research Application
• Pain
• Nociception
• Analgesia
• Neuronal development
Research Area
Pain

Characteristics

Characteristics
• Homozygous knockout rats exhibit complete loss of p75NTR protein
• p75NTR knockout rats show hyposensitivity to thermal pain via hot plate assay
• p75NTR knockout rats show increased reactivity to touch in a functional observational battery (Irwin)
Background Strain: Sprague-Dawley
Figure 1
p75NTR Knockout Rat - Figure 1
Figure 1: Thermal insensitivity in p75NTR knockout rats.
p75NTR knockout rats show increased foot licking latency in the hot plate test.
*** = p < 0.001.
Additional Information

Additional Information

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