Oat1 Knockout Rat

TGRS6440

Animal Model
slc22a6

Nomenclature
SD- slc22a6 tm1sage

Zygosity Genotype
Cryopreserved as heterozygous embryos

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a biallelic deletion of the organic anion transporter 1 (OAT1), also known as solute carrier family 22 member 6 (SLC22A6). Oat1 plays a central role in renal organic anion transport. Along with Oat3, Oat1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys- making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)

Research Applications

Research Application
• Drug transport
• Drug-drug interactions
• Drug metabolism
• Hepatotoxicity
Research Area
Uptake Transporters
Additional Information

Additional Information

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