This model contains a biallelic deletion of the Neurexin 1 gene (Nrxn1). Mutations in Nrxn1 have been associated with autism spectrum disorders (ASD) and this model is useful for understanding the role of neurexins in the development of ASD.
• This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine • Deletions in Neurexin 1 are present in ~0.5% of patients with ASD • Copy number variations in Neurexin 1 have been linked to both ASD and schizophrenia • Neurexins are important for postsynaptic differentiation, especially so for GABA synaptic connections • Background Strain: Sprague-Dawley
Figure 1: 16 bp deletion within Exon 1 Neurexin 1 knockout rats possess a 16 bp deletion (red) in Exon 1 (white). The blue region represents the ZFN binding site.