Neurexin1 - Nrxn1 Knockout Rat

TGRA6160

Animal Model
Nrxn1

Nomenclature
SD- Nrxn1 tm1sage

Zygosity Genotype
Heterozygous

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a biallelic deletion of the Neurexin 1 gene (Nrxn1). Mutations in Nrxn1 have been associated with autism spectrum disorders (ASD) and this model is useful for understanding the role of neurexins in the development of ASD.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Autism
• Schizophrenia
• Synaptic plasticity
Research Area
Autism

Characteristics

Characteristics
• This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine
• Deletions in Neurexin 1 are present in ~0.5% of patients with ASD
• Copy number variations in Neurexin 1 have been linked to both ASD and schizophrenia
• Neurexins are important for postsynaptic differentiation, especially so for GABA synaptic connections
Background Strain: Sprague-Dawley
Figure 1
Neurexin1 - Nrxn1 Knockout Rat - Figure 1
Figure 1: 16 bp deletion within Exon 1
Neurexin 1 knockout rats possess a 16 bp deletion (red) in Exon 1 (white). The blue region represents the ZFN binding site.
Protocols & Documents
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