MSI FFPE DNA Reference Standard

Format
FFPE

Description

This MSI Reference standard contains 20 biomarkers relevant to determining the status of MSI in a patient sample, including markers in the National Cancer Institutes’ standardised Bethesda panel.


Our reference standards are cell line-derived, for the closest representation of patient samples.


A matched MSS reference standard is also available: HD831


**Special offer! 25% off when you buy both MSI and MSS reference standards. **
Available for a limited time only. Discount is automatically applied at checkout.


Product Flyer

HD830
$203.00

Availability: In Stock

25% off when you purchase with our MSS reference standard (HD831)!

Bulk order discount
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Technical Information

Microsatellites are repetitive sequences. Microsatellite Instability (MSI) relates to the misfunction of the DNA Mismatch Repair (MMR) gene that can introduce errors, in length or sequence, that result in novel repetitive sequences. MSI is most closely associated with colon cancers but shows prevalence in multiple other cancer types.

MSI is used in cancer diagnostics to aid the determination of an appropriate course of treatment for a patient. qPCR and NGS workflows are used to determine MSI status in patient samples. This standard has been shown to work with the Promega MSI kit, the Titano MSI kit, the Biocartis Idylla MSI kit and a laboratory developed test which utilises the Illumina MiSeq Sequencer.


Technical Data

Fixation Method
4% PFA
Section Size
15µm
Cell Density
250 million cells per 1cm core
Expected DNA Yield
400ng per section using Promega

Product Information

Verified Mutations
Verified as instable during QC: BAT-26, BAT-25, MONO-27, NR-21, NR-24. Confirmed as instable during development: BTBD7, DIDO1, ACVR2A, SEC31A, MRE11, SULF2, RYR3, BAT-40, TGFβ-11, D2S123, D18S58, D5S346, CAT-25, NR-22 and NR-27
Unit Size
1 section
Intended Use
Research Use Only

General Information

Allelic Frequency
No
Storage
2-8ᵒC

Quality Control

Quality
Biomarkers confirmed with Promega MSI Kit
Protocols & Documents

Please browse our collection of downloads below.

If you need any support, advice or additional documentation then don't hesitate to contact us here.

Certificate of Analysis

Batch ID: 38133
PDF Download
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