mGluR5 Knockout Rat

TGRA6020

Animal Model
Grm5

Nomenclature
SD- Grm5 tm1sage

Zygosity Genotype
Heterozygous

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). mGluR5 function is altered in Fragile X syndrome, and mGluR5 has emerged as a promising drug target for both Fragile X syndrome and autism spectrum disorders.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Autism
• Fragile X syndrome
• Cognition
• Schizophrenia
• Anxiety
• Pain
Research Area
Autism

Characteristics

Characteristics
• mGluR5 is implicated in the neuropharmacology of cognition, anxiety, addiction and pain
• The function of this receptor is altered in Fragile X syndromem
• GlurR5 antagonists are being pursued as potential therapeutics for Fragile X syndrome and autism spectrum disorders
Background Strain: Sprague-Dawley
Figure 1
mGluR5 Knockout Rat - Figure 1
Figure 1: mGluR5 knockout rats lack mGluR5 protein as determined by Western blot. Actin bands demonstrate equal sample loading.
Protocols & Documents
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