MeCP2 Knockout Rat

TGRA6090

Animal Model
Mecp2

Nomenclature
SD- Mecp2 tm1sage

Zygosity Genotype
Heterozygous Females

Colony Size
Cryopreserved

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
This model contains a deletion of the methyl-CpG-binding protein (MeCP2)and is useful for the study of Rett syndrome. Mutations in MeCP2 have been linked to the development of Rett syndrome, a leading cause of intellectual disabilities in girls.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Autism
• Rett syndrome
• Cognition
Research Area
Autism

Characteristics

Characteristics
• Knockout rats exhibit complete loss of target protein as demonstrated by Western blot
• Mutations in methyl-CpG-binding protein (MeCP2) result in Rett syndrome, a leading cause of intellectual disabilities in girls
Background Strain: Sprague-Dawley
Figure 1
MeCP2 Knockout Rat - Figure 1
Figure 1: Loss of MeCP2 protein in MeCP2 knockout rats
MeCP2 protein expression is disrupted in MeCP2 knockout rats as compared to wild type controls as demonstrated by Western blot. Actin staining demonstrates equal sample loading.
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