MeCP2 Knockout Rat


Animal Model

SD- Mecp2 tm1sage

Zygosity Genotype
Heterozygous Females

Colony Size

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Unit Price

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Availability: In stock


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Technical Information
This model contains a deletion of the methyl-CpG-binding protein (MeCP2)and is useful for the study of Rett syndrome. Mutations in MeCP2 have been linked to the development of Rett syndrome, a leading cause of intellectual disabilities in girls.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Autism
• Rett syndrome
• Cognition
Research Area


• Knockout rats exhibit complete loss of target protein as demonstrated by Western blot
• Mutations in methyl-CpG-binding protein (MeCP2) result in Rett syndrome, a leading cause of intellectual disabilities in girls
Background Strain: Sprague-Dawley
Figure 1
MeCP2 Knockout Rat - Figure 1
Figure 1: Loss of MeCP2 protein in MeCP2 knockout rats
MeCP2 protein expression is disrupted in MeCP2 knockout rats as compared to wild type controls as demonstrated by Western blot. Actin staining demonstrates equal sample loading.
Protocols & Documents
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