Mdr1a Knockout Rat

TGRS3570

Animal Model
Abcb1a

Nomenclature
SD- Abcb1a tm1sage

Zygosity Genotype
Homozygous

Colony Size
Readily Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
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P-glycoprotein plays a critical role in efflux for both brain and liver. Homozygous null Mdr1a rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp-specific substrates.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• DMPK Assay
• PK/PDEfflux Assay
• Neurotoxicology
• Formulation Drug-drug interactions
• Drug resistance
• Blood brain barrier efflux
• Efficacy
Research Area
Efflux Transporters

Characteristics

Characteristics
• Biallelic 20 bp deletion within Abcba1 gene
• Increased oral bioavailability of P-gp-specific substrates
• Homozygous knockout rats display total loss of protein via Western blot
Background Strain: Sprague-Dawley
Figure 1
Mdr1a Knockout Rat - Figure 1
Figure 1: Oral absorption of Digoxin in the absence and presence of Quinidine
Figure 2
Mdr1a Knockout Rat - Figure 2
Figure 2. Western blot using proximal colon tissue isolated from both wild type and Mdr1a homozygous knockout tissue
Protocols & Documents
Additional Information

Additional Information

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