Lrrk2 Knockout Rat

TGRL4620

Animal Model
Lrrk2

Nomenclature
LEH- Lrrk2 tm1sage

Zygosity Genotype
Homozygous

Colony Size
Readily Available

$475.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2. Mutations in Lrrk2 are the most common monogenic cause of Parkinson's disease. This model is useful in understanding Lrrk2 biology.
Download our review of Animal Models of Parkinson's Disease.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
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Research Applications

Research Application
• Parkinson's disease
• Neuronal apoptosis
Research Area
Parkinson's Disease

Characteristics

Characteristics
• Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
• Lrrk2 knockout rats display dark kidneys, similar to observations made in Lrrk2 knockout mice
• Lrrk2 knockout rats are significantly larger than wild type controls
Background Strain: Long Evans Hooded
Figure 1
Lrrk2 Knockout Rat - Figure 1
Figure 1: Kidney pathology in Lrrk2 knockout rats
Kidney from a Lrrk2 knockout rat at 37 weeks of age. The kidney is dark in color, a phenotype similar to observations in Lrrk2 knockout mice (Herzig MC, et al. Hum Mol Genet (2011) 20 (21): 4209-4223). Image courtesy of PsychoGenics.
Figure 2
Lrrk2 Knockout Rat - Figure 2
Figure 2. Rotarod performance of Lrrk2 knockout rats at 12 months of age
Lrrk2 knockout animals show no deficits in motor activity as assessed by rotarod at 12 months of age.
Protocols & Documents
Additional Information

Additional Information

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