Lrrk1-Lrrk2 Knockout Rat

TGRL6720

Animal Model
Lrrk1-Lrrk2

Nomenclature
LEH- Lrrk1-Lrrk2tm1sage

Zygosity Genotype
Cryopreserved as heterozygous embryos

Colony Size
Cryopreserved

$475.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Developed in collaboration with The Michael J. Fox Foundation, this model is a double knockout that contains deletions of both the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2, as well as the Lrrk1 gene, encoding for the leucine-rich repeat kinase 1. Mutations in Lrrk2 are the most common monogenic cause of Parkinson's disease. This model is useful in understanding Lrrk biology.
Download our review of Animal Models of Parkinson's Disease.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve
Health Report
PDF Download

Research Applications

Research Application
• Parkinson's disease
• Neuronal apoptosis
Research Area
Parkinson's Disease

Characteristics

Characteristics
Background Strain: Long Evans Hooded

Publications

Publications
Lrrk1/Lrrk2 Health Report
Protocols & Documents
Reviews

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