Custom Model Generation
Let us design your ideal animal model with our custom model generation service
Looking for a CRISPR mouse or rat model not included in our existing model catalog?
tHorizon Discovery's in vivo custom model generation specialists can work with you to design and deliver a genetically engineered animal model to your exact specifications, using our CRISPR-Cas9* or Zinc Finger Nuclease technologies, in as few as 5 months.
Beyond constitutive gene knockouts, we offer more sophisticated project types - humanized, conditional knockouts, point mutations and reporter tagging.
*licensed by Caribou Biosciences and the Broad Institute
Your custom model generation project with Horizon Discovery includes:
Typical timelines for animal model generation (in months):
* Stable gene expression Safe Habor Locus (Rosa26)
Download our whitepaper on the advantages of using CRISPR/Cas9 for animal model generation.
Animal Research Models of Human Disease
As CRISPR-Cas9 and ZFN technologies directly enable targeted mutagenesis at the single cell stage, embryonic stem cells are not required - making custom model generation much faster and without background strain limitations.
These technologies are utilized to generate sequence-specific double-strand breaks that are repaired by error-prone Non-Homologous End Joining (NHEJ) or high-fidelity homologous recombination (HR).