Xenobiotic Sensors

Investigate the drug metabolism of your compound with confidence with Horizon’s PXR, CAR, and AHR Single, Double and Triple Knockout Rats.

The pregnane X receptor (PXR), the constitutive androstane receptor (CAR), and the aryl hydrocarbon receptor are involved in the induction of cytochrome p450 and related genes and are abundantly expressed in the liver and intestine. These models are useful for studying metabolism of xenobiotic compounds and hepatotoxicity.

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Currently Available Xenobiotic Sensor Rats:
PXR CAR AHR
PXR/CAR PXR/CAR/AHR PPARa

Xenobiotic brochure

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