Cox2 Knockout Rat

TGRS5040

Animal Model
Cox2

Nomenclature
SD- Cox2 tm1sage

Zygosity Genotype
Cryopreserved as heterozygous embryos

Colony Size
Cryopreserved

$475.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
COX2 is one of the isoenzymes from Cyclooxygenase (COX) family and is responsible for inflammation and pain. Several pain relieving drugs such as Celecoxib and Rofecoxib selectively target COX2.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Age Weight Curve

Research Applications

Research Application
• Rheumatoid arthritis
• Inflammation/Autoimmune disorders
• Asthma
• Multiple sclerosis
• Thrombosis/Cardiac fibrosis
• Vascular defects
• Platelet defects/Platelet aggregation
• Renal dysplasia
• Crohn's disease
• Colitis
Research Area
Immunology/Inflamation

Characteristics

Characteristics
• Homozygous knockouts display loss of COX2 protein via Western blot
Background Strain: Sprague-Dawley
Figure 1
Cox2 Knockout Rat - Figure 1
Figure 1: Homozygous knockout rats display loss of COX2 protein
Peritoneal macrophages were isolated from a wild type or a Cox2 homozygous knockout (COX2 -/-) rat and cultured in the presence or absence of LPS overnight. Lysates from these cultured macrophages were subjected to Western blot with the anti-COX2 antibody from Cell Signaling Technology (#4842). Rat COX2 protein is ~74 kDa.
Additional Information

Additional Information

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