Cancer-related cell lines

Choose from over 300 knock-in and knockout cell line models in many standard cancer cell lines such as DLD1, MCF10A, and HCT116.

KDM5C ( Human )

Entrez Gene 8242 entrezgene 8242
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lysine demethylase 5C

Alias

DXS1272E | JARID1C | MRX13 | MRXJ | MRXSCJ | MRXSJ | SMCX | XE169

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].

Recapitulate disease phenotypes

Endogenous knock-in cell lines enable a clear understanding of a gene or mutation’s contribution to a phenotype including conditional knockouts to model human disease

Confirm your results

We provide truly isogenic cell line pairs. Each cell model comes with the parental cell line as an additional control

Knockout and knock-in models

Our knock in models have more complex genetic modifications such as:

  • insertions
  • base pair changes
  • deletions
  • truncations
  • FLAG-tagged proteins for purification

Proven models

Our catalog of cell lines has become a gold-standard resourceciteab-award-cell-line-supplier-to-watch-in-cancer-research in antibody validation, cancer research, and early drug-discovery research. Horizon was recently recognized by CiteAb as the Cell Line Supplier to Watch in Cancer Research for 2024. Read more about the CiteAb award.

 

Limited use agreement

All cell lines engineered by Horizon Discovery are purchased under the terms of our Limited Use Label License.