hApoE4 Knock-In Rat

TGRA8960

Animal Model
hApoE4KI

Nomenclature
SD- hApoE4KItm1sage

Zygosity Genotype
Homozygous

Colony Size
Readily Available

$525.00

Availability: In stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

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Technical Information
Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Additionally, the 4 allele of ApoE (ApoE4) is a major risk factor for Alzheimer's disease (AD), with possession of at least one ApoE4 allele in 40–65% of patients with AD and a patient with 2 ApoE4 alleles having up to 20 times the risk of developing AD.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)
Health Report
PDF Download

Research Applications

Research Application
• Alzheimer's disease
• Neurodegenerative diseases
Research Area
Alzheimer's Disease

Characteristics

Characteristics
• Homozygous replacement of the Rat ApoE gene with the Human ApoE4 gene
Background Strain: Sprague-Dawley
Figure 1
hApoE4 Knock-In Rat - Figure 1
Figure 1: Humanized Knock-in Validation of the ApoE4 5' junction, 3' junction, and Donor Cassette via PCR. PCR analysis to show targeted integration of the humanized donor cassette.
Additional Information

Additional Information

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