CFTR Knockout Rat

TGRS5740

Animal Model
Cftr

Nomenclature
SD- Cftr tm1sage

Zygosity Genotype
Heterozygous

Colony Size
Cryopreserved

$525.00

Availability: Out of stock

Please note: Commercial pricing applied and includes the price of the animal model only. Academic pricing available on quote request.

Technical Information
CFTR knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (CFTR), resulting in loss of protein expression.

Technical Data

Diet Value
LabDiet #5R24 (RMH2500)

Research Applications

Research Application
• Cystic Fibrosis
• Chloride transport
• Thiocyanide transport
Research Area
Cystic Fibrosis

Characteristics

Figure 1
CFTR Knockout Rat - Figure 1
Figure 1:Proximal nasal histology and nasal potential difference measurements in CFTR knockout rats.
(A) Low power magnification (4×) H&E stained sections from the proximal nasal passages bar = 500 µm. 20× images of ABPAS stained nasal septa from boxed areas bar = 25 µm. Arrowheads, cells swollen with intracellular mucus; e, respiratory epithelium; g, submucosal gland; dashed line (–), basement membrane (n = 4 animals/group) (B) NPD tracings from wild-type and CFTR-/- rats.
Summary data from NPD measurements for: amiloride, Cl--free Ringers, forksolin, and Cl-/-free Ringers+forskolin. (n = 5 animals/group) **p=0.01.
Tuggle KL, et al. (2014) PLoS ONE 9(3): e91253.
Protocols & Documents
Additional Information

Additional Information

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