Horizon Isogenic human cell line pairs provide a model system for the study of the role of genes in cellular processes and drug responses. Cell lines are provided with a matched wild type control parental cell line ensuring phenotypes can be attributed directly to the requested genetic modification(s). Some common uses of cell lines are:
These models complement and surpass non isogenic cell lines where findings are difficult to understand due to the absence of a normal control cell.
|Data Showcase: Using Horizon Cell Lines for Functional Studies|
Olaparib sensitivity in normal and BRCA2 (-/-) Knockout Cell Lines; Cell Lines allow the role of specific genes to be studied without the influence of other factors. Data above demonstrates the sensitivity of BRCA2 knockout cell lines to Olaparib, a PARP inhibitor compared to Gemcitabine a chemotherapy drug.
Differential sensitivities to EGFR inhibitors in normal and EGFR Knockin Cell Lines; Isogenic cell lines allow the role of specific genes to be studied without the influence of other factors. The data above shows the anti-proliferative effects of the EGFR inhibitors gefitinib and erlotinib on cell lines containing different engineered EGFR mutants [EGFR ∆E746-A750; EGFR L858R, EGFR T790M] in 96hr proliferation assays.
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For offline access, many of our popular cell lines that are usually available for immediate delivery are listed in our downloadable catalog - your gene edited cell line may have already been created!