What is Ubiquitin?
Definition: Ubiquitin is a small regulatory protein found in the majority of eukaryotic tissues and is added to lysine residues of proteins as a post-translational modification.
|The addition of ubiquitin can impact on protein regulation in a number of ways including degradation, cellular localisation, protein interactions and activity. These modifications can have diverse effects on a number of major cellular processes such as apoptosis, cell cycle, immune regulation and DNA transcription and repair amongst many others.|
|Ubiquitin is attached to lysine residues in the target protein by a series of 3 main reactions:|
The manner in which ubiquitin is added determines the outcome for the protein. These modifications can include:
These modifications alter cellular process in different ways. For example, monubiquitination can impact on membrane trafficking; however, some forms of polyubquitination can result in a protein being targeted for degradation via the proteasome. The ubiquitin pathway has been implicated in a number of genetic disorders and diseases including cancer and neurological diseases which result from the build-up of protein aggregates such as; Alzheimer’s disease, Parkinson’s disease and Huntingdon’s disease.
|Examples of popular knockout cell lines|
Our cell line range is constantly growing. For our most current list of ready-made cell lines and details of custom made engineering projects you can browse our entire offering via the link below.
For offline access, many of our popular cell lines that are usually available for immediate delivery are listed in our downloadable our catalog - your gene edited cell line may already have been created!