Cell Lines For Studying Solute Carrier (SLC) Genes

What are Solute carriers?

Definition: The majority of solute carriers reside in the cell membrane where they regulate the cellular uptake of a diverse range of solutes, such as sugars, amino acids, nucleotides, inorganic ions and drugs. Some solute carriers also reside on intracellular organelles.

Solute carriers are the second largest group of membrane proteins. Current estimates are that there are almost 400 members which can be divided into 52 families.

They can participate in two main forms of transportation:

  • Facilitative or passive, where solutes flow with their electrochemical gradient
  • Secondary active transporters, which allow solutes to move against their electrochemical gradient through coupling to a second solute flowing with its gradient.
Solute carrier diagram
Due to the diverse nature of the solutes carried by this large family of proteins they are implicated in a wide variety of processes from neurosignalling, nucleoside synthesis and salvage to transportation drugs.
Examples of popular knockout cell lines
MTCH1SLC25A18SLC30A1SLC39A8
SLC11A2SLC25A20SLC30A3SLC39A9
SLC12A4SLC25A22SLC30A5SLC41A3
SLC12A5SLC25A25SLC30A7SLC43A1
SLC12A6SLC25A29SLC31A1SLC43A2
SLC12A7SLC25A3SLC33A1SLC43A3
SLC12A9SLC25A30SLC34A2SLC44A1
SLC16A10SLC25A32SLC35A1SLC46A3
SLC16A13SLC25A37SLC35A3SLC4A10
SLC16A3SLC25A38SLC35A5SLC4A2
SLC17A5SLC25A4SLC35C1SLC4A8
SLC17A9SLC25A40SLC35E2BSLC52A2
SLC19A1SLC25A46SLC35F2SLC5A4
SLC1A4SLC25A5SLC36A4SLC5A6
SLC1A5SLC25A6SLC37A4SLC7A1
SLC20A2SLC26A2SLC38A10SLC7A3
SLC22A18SLC27A1SLC38A2SLC7A6
SLC22A5SLC27A2SLC38A5SLC9A3R1
SLC25A1SLC27A3SLC38A9SLC9A3R2
SLC25A10SLC27A4SLC39A1SLC9A7
SLC25A11SLC29A1SLC39A14SLC9C1
SLC25A13SLC29A4SLC39A3UCP1
SLC25A15SLC2A8SLC39A6 

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For offline access, many of our popular cell lines that are usually available for immediate delivery are listed in our downloadable our catalog - your gene edited cell line may already have been created!

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