What are Solute carriers?
Definition: The majority of solute carriers reside in the cell membrane where they regulate the cellular uptake of a diverse range of solutes, such as sugars, amino acids, nucleotides, inorganic ions and drugs. Some solute carriers also reside on intracellular organelles.
Solute carriers are the second largest group of membrane proteins. Current estimates are that there are almost 400 members which can be divided into 52 families.
They can participate in two main forms of transportation:
|Due to the diverse nature of the solutes carried by this large family of proteins they are implicated in a wide variety of processes from neurosignalling, nucleoside synthesis and salvage to transportation drugs.|
|Examples of popular knockout cell lines|
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