Cell Lines For Studying Solute Carrier (SLC) Genes

What are Solute carriers?

Definition: The majority of solute carriers reside in the cell membrane where they regulate the cellular uptake of a diverse range of solutes, such as sugars, amino acids, nucleotides, inorganic ions and drugs. Some solute carriers also reside on intracellular organelles.

Solute carriers are the second largest group of membrane proteins. Current estimates are that there are almost 400 members which can be divided into 52 families.

They can participate in two main forms of transportation:

  • Facilitative or passive, where solutes flow with their electrochemical gradient
  • Secondary active transporters, which allow solutes to move against their electrochemical gradient through coupling to a second solute flowing with its gradient.
Solute carrier diagram
Due to the diverse nature of the solutes carried by this large family of proteins they are implicated in a wide variety of processes from neurosignalling, nucleoside synthesis and salvage to transportation drugs.
Examples of popular knockout cell lines
MTCH1 SLC25A18 SLC30A1 SLC39A8
SLC11A2 SLC25A20 SLC30A3 SLC39A9
SLC12A4 SLC25A22 SLC30A5 SLC41A3
SLC12A5 SLC25A25 SLC30A7 SLC43A1
SLC12A6 SLC25A29 SLC31A1 SLC43A2
SLC12A7 SLC25A3 SLC33A1 SLC43A3
SLC12A9 SLC25A30 SLC34A2 SLC44A1
SLC16A10 SLC25A32 SLC35A1 SLC46A3
SLC16A13 SLC25A37 SLC35A3 SLC4A10
SLC16A3 SLC25A38 SLC35A5 SLC4A2
SLC17A5 SLC25A4 SLC35C1 SLC4A8
SLC17A9 SLC25A40 SLC35E2B SLC52A2
SLC19A1 SLC25A46 SLC35F2 SLC5A4
SLC1A4 SLC25A5 SLC36A4 SLC5A6
SLC1A5 SLC25A6 SLC37A4 SLC7A1
SLC20A2 SLC26A2 SLC38A10 SLC7A3
SLC22A18 SLC27A1 SLC38A2 SLC7A6
SLC22A5 SLC27A2 SLC38A5 SLC9A3R1
SLC25A1 SLC27A3 SLC38A9 SLC9A3R2
SLC25A10 SLC27A4 SLC39A1 SLC9A7
SLC25A11 SLC29A1 SLC39A14 SLC9C1
SLC25A13 SLC29A4 SLC39A3 UCP1
SLC25A15 SLC2A8 SLC39A6  

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For offline access, many of our popular cell lines that are usually available for immediate delivery are listed in our downloadable our catalog - your gene edited cell line may already have been created!

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